Job Summary
The Senior Principal Statistical Programmer serves as a senior technical leader and subject matter expert in statistical programming, with deep expertise supporting clinical trials and Data Monitoring Committee (DMC) deliverables. This role combines advanced hands-on programming capabilities with technical leadership, driving the design, development, and standardization of high-quality statistical outputs. The Senior Principal Statistical Programmer independently leads complex programming initiatives, provides expert-level guidance across projects, and plays a key role in shaping programming standards, tools, and best practices. This role partners closely with biostatistics, project management, data management and cross-functional stakeholders to ensure high-quality, compliant, and efficient delivery of programming outputs.
ESSENTIAL DUTIES/RESPONSIBILITIES: To perform this job successfully, an individual must be able to perform each essential duty and responsibility satisfactorily. The accountabilities listed below are representative of the knowledge, skills, and/or ability required.
Serve as a senior technical expert in statistical programming, providing guidance across multiple studies or functional areas.
Design, develop, validate, and oversee complex statistical programming deliverables, including analysis datasets, tables, listings, and figures.
Lead the development, validation, and continuous improvement of DMC macros and programming standards.
Provide technical oversight and review of programming work to ensure quality, compliance, and consistency across deliverables.
Drive the establishment and adoption of programming standards, best practices, and process improvements.
Collaborate with biostatistics and study teams to support complex trial designs, analyses, and DMC reporting.
Independently manage and prioritize programming activities across multiple studies or initiatives.
Mentor and provide technical leadership to statistical programming staff, supporting skill development and best practices.
Contribute technical expertise to proposals, project planning, and scope discussions as needed.
Partner with IT and technology teams to support SAS environments, tools, and system validation efforts.
Provide technical oversight for programming activities supporting regulatory submissions and inspection readiness.
Ensure programming deliverables align with regulatory expectations, submission requirements, and CDISC standards.
Influence programming approaches, standards, and best practices across multiple studies or programs.
Serve as a technical escalation point for complex programming, data, or deliverable issues, leading resolution of highly complex or ambiguous challenges.
Provide expert interpretation of statistical analysis plans (SAPs), protocols, and study documents, translating requirements into programming strategy.
Champion process improvements, automation, and innovative approaches to enhance efficiency, scalability, and consistency of programming deliverables.
Other duties as assigned by supervisor. These may, on occasion, be unrelated to the position described here.
EDUCATION REQUIREMENTS: Master’s degree required. In limited circumstances, an equivalent combination of education and directly relevant professional experience may be considered.
QUALIFICATIONS/EXPERIENCE
Minimum 8–10 years of statistical programming experience in a clinical trial environment.
Deep expertise in SAS programming, including complex analyses and regulatory deliverables.
Proficiency in R programming is a must.
Demonstrated experience with CDISC standards and regulatory requirements.
Proven ability to independently lead complex programming efforts across studies.
Experience mentoring staff and driving technical standards or best practices.
Demonstrated ability to independently coordinate biostatistical projects, including planning and oversight of programming activities, with minimal direction from senior leadership.
TRAVEL REQUIREMENTS
☒ 0% – 5%
☐ 5% - 10%
☐ 10% - 20%
☐ 20% - 50%
☐ >50%
#LI-Remote
Pay Range
USD $131,100.00 - USD $160,000.00 /Yr.
EEOC Statement
WCG is proud to be an equal opportunity employer – Qualified applicants will receive consideration for employment based on merit and without regard to race, color, national origin or ancestry, religion or creed, sex, sexual orientation, gender expression, gender identity, age, marital status, family or parental status, disability, genetic information, citizenship, veteran status, or any other legally recognized basis or status protected by federal, state, or local law. WCG complies with the Vietnam Era Veterans' Readjustment Act and Section 503 of the Rehabilitation Act. We promote a "One WCG" culture where all are welcome, respected, valued, and empowered to make a difference every day to advance clinical research.
