Exceptional collaborations - Join a diverse, international team working across multiple projects and connect with scientific and clinical communities throughout Harvard, MIT, Mass General Brigham, and the Broad Institute.
Career development - Receive support for publications, conference presentations, independent fellowships, and the transition to your next career stage.
Qualifications
POSITION 1 | Chemistry & Materials Science for Long-Acting Therapeutics
Lead project design and execution, including the synthesis and characterization of novel materials and formulation strategies for long-acting injectable and implantable delivery systems. Potential applications include infectious-disease prevention and treatment, substance use disorder, hormonal therapy, and organ transplantation.
Core qualification
Ph.D. or equivalent in chemistry, bioengineering, chemical engineering, materials science, polymer science, pharmaceutical sciences, or a related field.
Experience in one or more of the following would be valuable
Polymer synthesis and characterization
Controlled-release formulations or long-acting drug-delivery systems
Release kinetics, degradation, mechanical or rheological characterization, and relationships to in vivo performance
Scalable and manufacturable formulation or fabrication processes
In vitro and in vivo pharmacokinetic evaluation
POSITION 2 | Non-Viral Delivery of Gene Therapies and Gene-Editing Tools
Lead the engineering and evaluation of lipid nanoparticles, polymeric carriers, and other non-viral systems for RNA therapeutics, gene therapies, and gene-editing tools such as CRISPR/Cas systems. Projects will address delivery efficiency, tissue and cell targeting, and safety in the brain, lung, and other difficult-to-reach tissues.
Core qualification
Ph.D. or equivalent in bioengineering, chemical engineering, molecular biology, pharmaceutical sciences, or a related field.
Experience in one or more of the following would be valuable
Non-viral delivery of nucleic acids, including mRNA, siRNA, or CRISPR/Cas components
Nanoparticle formulation and physicochemical characterization
Targeting, biodistribution, or pharmacokinetic studies
In vitro and in vivo efficacy studies, including expression, knockdown, or editing readouts
Adapting delivery technologies to new tissues and therapeutic targets
POSITION 3 | Immunology and Immunoengineering
Lead mechanistic studies defining the immunological dimensions of BTL's therapeutic platforms, including immunomodulation, neuroinflammation, and host responses to biomaterials and delivery systems. The goal is to use these insights to improve therapeutic safety and efficacy.
Core qualification
Ph.D. or equivalent in immunology, microbiology, molecular or cellular biology, or a related field. Prior experience in materials science or drug delivery is welcome but not required.
Experience in one or more of the following would be valuable
Immune responses to biomaterials, nanoparticles, or delivery platforms
Experimental models of immunomodulation or neuroinflammation
Flow cytometry, cytokine profiling, single-cell approaches, or related immunological assays
Mechanistic studies that connect immune responses with therapeutic performance
Close collaboration with materials- and delivery-focused scientists
We welcome candidates who have completed, or are nearing completion of, a Ph.D. or equivalent degree and who combine strong technical foundations with curiosity, creativity, and scientific rigor. Successful fellows take ownership of their work, bring initiative and an entrepreneurial mindset to project development, communicate clearly, and enjoy collaborating across disciplines. A strong publication record is valued, but we will consider accomplishments in the context of each candidate's opportunities, field, and career stage.
Fellows are expected to develop and execute rigorous studies, communicate findings through publications and scientific presentations, contribute positively to the lab community, and pursue opportunities for increasing scientific independence.
The salary for this position ranges from $71,750 to $73,544 annually.
Learn more: www.thejoshilab.com
Additional Job Details (if applicable)
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Curriculum vitae, including a complete publication list
Cover letter describing your research interests, relevant experience, career goals, and the position(s) for which you wish to be considered
Names and contact information for three references
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Remote Type
Onsite
Work Location
60 Fenwood Road
EEO Statement
2200 The Brigham and Women's Hospital, Inc. is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religious creed, national origin, sex, age, gender identity, disability, sexual orientation, military service, genetic information, and/or other status protected under law. We will ensure that all individuals with a disability are provided a reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. To ensure reasonable accommodation for individuals protected by Section 503 of the Rehabilitation Act of 1973, the Vietnam Veteran’s Readjustment Act of 1974, and Title I of the Americans with Disabilities Act of 1990, applicants who require accommodation in the job application process may contact Human Resources at (857)-282-7642.
Mass General Brigham Competency Framework
At Mass General Brigham, our competency framework defines what effective leadership “looks like” by specifying which behaviors are most critical for successful performance at each job level. The framework is comprised of ten competencies (half People-Focused, half Performance-Focused) and are defined by observable and measurable skills and behaviors that contribute to workplace effectiveness and career success. These competencies are used to evaluate performance, make hiring decisions, identify development needs, mobilize employees across our system, and establish a strong talent pipeline.
