Crystallization is where chemistry becomes medicine — the step that determines whether a promising molecule can be reliably purified, formulated, and manufactured at scale. We're looking for an outstanding crystallization engineer to join our Crystallization Science team and take ownership of that critical transformation across an exciting and diverse pipeline of small molecules, oligonucleotides, and synthetic peptides.
You'll work in a brand-new, pioneering development facility in Indianapolis, embedded in a highly collaborative environment alongside synthetic chemists, analytical scientists, formulation experts, and process engineers — with the resources and cross-functional support to solve genuinely hard problems, not just implement someone else's protocol.
What We're Looking For
An engineer with strong technical depth in crystallization science and engineering, a track record (or clear potential) for scientific leadership, solid understanding of cGMP and ICH guidelines (Q6A, Q8, Q11), and — just as important — a genuine passion for collaborative, team-based problem solving in a diverse and inclusive environment.
What You'll Do
Lead crystallization process design end-to-end — from first-principles science (nucleation kinetics, crystal growth, supersaturation control, solubility thermodynamics, heat/mass transfer) through robust, scalable processes that deliver clinical trial materials on time and on spec.
Innovate across a full toolkit of crystallization strategies — cooling, antisolvent, reactive, and seeded crystallization — paired with modern PAT tools (in-situ imaging, FBRM, ATR-FTIR, Raman) and QbD/DoE methodologies to build deep process understanding and real control, not just documentation.
Be the go-to crystallization expert on integrated drug substance project teams, driving particle engineering strategy (size distribution, morphology, polymorphic form, impurity rejection) and directly influencing regulatory filings (IND, IMPD, NDA) through your own authored content.
Bridge bench to plant to patient — partner with formulation, analytical, and manufacturing teams to ensure the APIs you develop translate into drug products that actually work, and lead scale-up and technology transfer to pilot plants and external CMOs.
Grow as a scientific leader — mentor emerging talent, publish and present in venues like AIChE and ACS, and help shape standards and control strategies across the broader organization.
Stay at the leading edge — engage with academic partners, pre-competitive consortia, and the latest advances in continuous crystallization and particle engineering as part of a culture that values external scientific contribution.
Minimum Qualifications
PhD in Chemical Engineering
MSc in Chemical Engineering +7 years of experience
BSc in Chemical Engineering +10 years of experience
Additional Skills and Preferences
Hands-on experience designing, developing, and optimizing crystallization processes for pharmaceutical APIs — including polymorph screening, solid-form selection, and particle engineering.
Fluency with crystallization modeling and simulation tools (population balance modeling, thermodynamic solubility modeling), plus a data-driven approach to DoE and process analytics.
Work across both batch and continuous unit operations, with a solid grasp of the technical considerations behind equipment design, process monitoring, and PAT system integration.
A natural communicator — someone who can distill complex technical work into clear documentation and compelling presentations for audiences ranging from bench scientists to regulatory reviewers.
A track record of thriving in multidisciplinary teams, where influence comes from expertise and collaboration rather than title alone.
Leadership instincts: someone who leans into challenges, proactively clears roadblocks, and can lead through ambiguity even without formal authority.
A collaborative, team-first attitude paired with strong interpersonal skills.
Sharp problem-solving instincts, close attention to detail, and a results-driven approach — even when the pace picks up.
Additional Information
Travel: 0 to 10%
Position Location: Indianapolis, IN LTC-N, onsite work 5 days/week.
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Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).
- Actual compensation will depend on a candidate’s education, experience, skills, and geographic location. The anticipated wage for this position is
- $130,500 - $211,200
Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.
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